Autism is a severe form of a group of disorders termed pervasive developmental disorders (PDD) and is characterized by impairments in social relatedness and communication skills and by unusual activities and interests such as rituals, stereotypes, and poor play skills. The overall prevalence of PDD is about 22 per 10,000 births. In most studies, the boy to girl ratio is 3:1 to 4:1. Due to their impairment in socialization and communication, dental treatment and dental habit become a challenge to caregivers as well as dentists. This article will review the general aspects of autism and discuss dental treatment for autistic patients.