The case of general education course of liberal arts ”natural science and music” was given at the academic year of 2000 till now. There were 1948 students enrolled in 31 classes during 10 years. Here, we describe the development of general education in Taiwan, the importance of the general education to the colleges and universities of technology, and the examples of「natural science and music」 course. In this study, we try to discuss the multiple dialogues between mathematics and music in order to provide a new concept to the courses of general education by the integration of technologies and humanities. Besides, we would review and list out the strategies and methods for carrying out the course as well as the reference model in order to realize the expected effects. Hopefully, we would like to share these experiences with the other colleges and universities for their general education.