利用蛋殼及植物皮萃取物合成奈米級氫氧基磷灰石

Synthesis of Nanohydroxyapatite Using Eggshell and Plant Peel Extracts

何文福(Wen-Fu Ho) ； 劉書蘋(Shu-Ping Liou) ； 吳世經(Shih-Ching Wu) ； 許學全(Hsueh-Chuan Hsu) ； 許世光(Shih-Kuang Hsu)

《科學與工程技術期刊》 10卷1期 (2014/03) Pp. 21-26

摘要

氫氧基磷灰石（Ca10(PO4)6(OH)2, HA）相似於人體骨骼和牙齒的礦物成分，由於其良好的生物相容性和生物活化性，因此廣泛的應用在包括骨填料、表面塗層以及支架上。由於奈米級氫氧基磷灰石比一般的氫氧基磷灰石具有較高的表面能，因此具有更好的生物性質。特別的是，人體內的天然磷灰石含有約3-8%（w/w）的碳酸鹽，此外，也預計奈米級氫氧基磷灰石將有更好的生物活性。本實驗是想要利用仿生法的過程來合成創造新的材料，也就是說，無機物和一個複雜的有機高分子的基質蛋白、多醣或脂類結合，不僅可控制合成粉末顆粒的大小和形狀，同時也能控制粉末顆粒團聚現象發生。本研究係利用水熱法，將碳酸鈣（CaCO3）和磷酸（H3PO4）溶液在密閉的高壓力釜中產生反應。實驗結果發現，添加植物皮萃取物在150°C持溫48 h，pH值為10的條件下，可以得到單相的棒狀奈米級氫氧基磷灰石結晶相。此外，蛋殼和生物分子的有效利用，可以大大提高經濟效率以及減少對環境的污染。

關鍵字

蛋殼 ； 氫氧基磷灰石 ； 奈米粒子 ； 水熱法 ； 生物分子

並列摘要

Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is similar to the mineral constituents of human bone and teeth. Because of its excellent biocompatibility and bioactivity, it is applied widely in bone fillers, surface coatings, and unloaded scaffolds. Nano-HA particles exhibit enhanced biological properties compared with normal HA particles because of their high surface energy and increased specific area. The natural apatite in the human body contains approximately 3%-8% (w/w) carbonate. Nanostructured HA is expected to have greater bioactivity than HA with coarser crystals does. Creating new synthetic materials by mimicking the processes involves combining minerals with a complex organic macromolecular matrix of proteins, polysaccharides and lipids to control the size and shape of synthesized particles. We used a hydrothermal method to create carbonate (CaCO3) and phosphoric acid (H3PO4) solutions that react with each other and form high pressure in a closed autoclave. A single phase of HA, the nanorod crystalline phase, was obtained when plant peel extracts were added and a temperature of 150°C and a pH value of 10 were maintained for 48 h. The effective use of eggshell and biomolecule waste greatly enhances economic efficiency and reduces environmental pollution.

並列關鍵字

eggshell ； hydroxyapatite(HA) ； nanoparticle ； hydrothermal method ； biomolecule