Under the 12-Year Basic Education Curricula, it is regulated that special education students can access to the general education curriculum even for students with significant cognitive disabilities (SCD) who are usually studied in self-contained classroom. Although the current education policy already provided students with SCD with the right to learn the general education curriculum, the recommendations of the effective teaching strategies requires more evidence-based practice. In this paper, the researchers introduced the evolution of the special education curriculum model in the United States and Taiwan at first, and then organized and discussed the evidence from the systematic review about the studies of learning general education curriculum for students with SCD.