- 期刊
Prognostic Significance of Vascular Endothelial Growth Factor-A Expression in Colorectal Cancer
並列摘要
AIM: To study the expression status and clinical relevance of vascular endothelial growth factor-A (VEGF-A) in cob rectal cancer (CRC) tissues. METHODS: VGF-A expression was investigated by immunohistochemistry in 89 cases with CRC. Some demographic and histopathologic variables were compared with VEGF-A expression to determine the prognostic significance in CRC. RESULTS: VEGF-A (-) was found in 24 cases; (+), (++) and (+++) stainings were detected in 24, 35 and 6 cases, respectively. VEGF-A (-) was found in 20 of 58 cases with left colon cancer, while only 4 of 31 cases with right colon cancer were VEGF-A (-)(P=0.024). There was a trend for lower tumor grade and lesser serosal invasion in cases with VEGF-A (-) samples (P=0.07 and P=0.079, respectively). Although the correlation was not statistically sigrificant, there was a trend for lower death rate in cases with VEGF-A (-) tumor (P=0.087). The longest survival was found In cases with VEGF-A (-) tumor and the shortest survival was found in cases with VEGF-A (+++) tumor. Median survival for patients with VEGF-A (-), (+), (++) and (+++) tumors was 59, 47, 35 and 11 months, respectively (P=0.02). The Cox proportional hazards model identified stage IV disease and VEGF-A (+++) tumor as having the most important influences upon overall survival (odds ratio: 5.1, 95% confidence interval: 2.0-13.0 and odds ratio: 3.6, 95% confidence interval: 1.0-12.7, respectively), followed by serosal all the known prognostic indicators. invasion (odds ratio: 2.4, 95% confidence interval: 1.0-5.9). CONCLUSION: This study shows that VEGF-A is a poor prognostic factor in cases with CRC but the relatively small size of the study group precluded the correlation with all the known prognostic indicators.
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