Acupuncture is a very important part of traditional medicine. It has been accumulated a large amount of clinical trails through many years, and was recognized as an effective treatment by World Health Organization. The fMRI, in another hand is an effective diagnostic instrument for brain's physiology and pathology to modern medicine. It can show that how local brain tissues act by detecting quantity, velocity and degree of deoxicidizing of circulation of brain cortex. It can also precisely show the morphology and functional activities of human brain. This article analyses the possible central mechanism of acupuncture therapy through the aspects of pain re1ief and post stroke patient's aphasia, dementia, and also collates the recent relative researches.