登山期間口服硫化脫氫異雄固酮鹽對生心理壓力指標及肌肉流失的影響

The Effect of Oral Dehydroepiandrosterone on Physiological Psychology Index and Muscle Loss during Mountain Climbing

楊孫錦(Sun-Chin Yang) ； 李文志(Wen-Chih Lee) ； 侯建文(Chien-Wen Hou) ； 王三財(San-Tsai Wang) ； 林勁宏(Ching-Hung Lin)

《運動教練科學》 36期 (2014/12) Pp. 47-63

https://doi.org/10.6194/SCS.2014.36.05

摘要

目的：探討短期攀登高山時補充脫氫異雄固酮鹽（dehydroepiandrosterone, DHEA）對生心理壓力指標及肌肉的流失的影響。方法：以14名健康男性自願受試者依體重平衡方式，均分為控制與DHEA組。研究為期六天，第一天先進行前測，測驗項目包括身體組成、胰島素阻抗、及血液生化值，其後開始每天服用菊醣安慰劑（控制組）或脫氫異雄固酮鹽（DHEA組）50毫克直至登山活動結束後。第三至五天為登山活動，登山結束後第六天進行與前測測驗項目相同之後測。除此之外於登山活動中，評估急性高山症反應及記錄受試者心跳率。結果顯示兩組皆於登山第二天時高山症自評量分數明顯高於第一天與第三天。結果：DHEA組之硫化DHEA（DHEA sulfate, DHEAS）濃度於後測時明顯高於前測（5.76±0.48 vs 3.22±0.36 ng/dl, p ＜ .05），同時也明顯高於控制組（5.76±0.48 vs 2.75±0.20 ng/dl, p＜.05）。兩組後測時可體松濃度皆明顯高於前測，但在後測兩組間無明顯差異。可體松與DHEAS濃度比值，控制組在後測明顯高於前測（6.10±0.55 vs 5.29±1.07, p＜.05），且在後測時控制組也明顯高於DHEA組（6.10±0.55 vs 3.43±0.47, p＜.05）。兩組在睪固酮濃度、脂肪重皆於後測明顯低於前測，但兩組間無差異存在。腫瘤壞死因子-α濃度與HOMA-IR指數於登山前後兩組間皆無明顯差異。結論：本研究主要發現補充脫氫異雄固酮鹽能於登山過程中，潛在增加體內抵抗生心理壓力的能力，但對肌肉流失無任何影響。

關鍵字

低氧 ； 可體松 ； 睪固酮

並列摘要

Purpose: this study aims to investigate the effect of oral dehydroepiandrosterone (DHEA) on physiological psychology index and muscle loss after the short-term high altitude mountain climbing. Method: 14 health volunteers (32.9±6.97 yrs old) were divided to placebo and DHEA groups by body weight balance. The pre-test included body composition, insulin sensitivity, and blood biochemical marker was carried out at first day, subsequently started taking inulin placebo (control group) or DHEA (DHEA group) until the fifth day. The mountaineering activities was implemented during third to fifth day and the post-test was carried out at sixth day. Besides the response of acute mountain sickness and heart rate were measured. Result: the mountain sickness self-assessment scores of both groups on the second day were significantly higher than the first and third day of mountaineering activities. The concentration of DHEA sulfate (DHEAS) in DHEA group was significantly higher at post- than pre-test, (5.76±0.48 vs 3.22±0.36 ng/dl, p＜.05), and higher than control group at pre-test (5.76±0.48及2.75±0.20 ng/dl, p＜.05). The cortisol level of both groups was higher at post- than pre-test, but not different between groups at post-test. The ratio of cortisol and DHEAS in control group was significantly higher at postthan pre-test (6.10±0.55 vs 5.29±1.07, p ＜ .05), and higher than DHEA group at pre-test (6.10±0.55 vs 3.43±0.47, p ＜ .05). The fat mass and testosterone level of both groups was lower at post- than pre-test, but not different between groups. Tumor necrosis factor-α and HOMA-IR index were not different between groups at postand pre-test. Conclusion: The main finding of this study that the ability of resistance for physiological psychology stress was increased by DHEA supplementation during mountain climbing, but not affected muscle loss.

並列關鍵字

hypoxia ； cortisol ； testosterone

參考文獻

Barnholt, K. E.,Hoffman, A. R.,Rock, P. B.,Muza, S. R.,Fulco, C. S.,Braun, B.(2006).Endocrine responses to acute and chronic high-altitude exposure (4,300 meters): Modulating effects of caloric restriction.The American Journal of Physiology-Endocrinology and Metabolism.290(6),E1078-1088.

Baumgartner, R. N.,Waters, D. L.,Gallagher, D.,Morley, J. E.,Garry, P. J.(1999).Predictors of skeletal muscle mass in elderly men and women.Mechanisms of Ageing and Development.107(2),123-136.

Bhasin, S.(2003).Testosterone supplementation for aging-associated sarcopenia.Journals of Gerontology Series A, Biological Sciences and Medical Sciences.58(11),1002-1008.

Binello, E.,Gordon, C. M.(2003).Clinical uses and misuses of dehydroepiandrosterone.Current Opinion in Pharmacology.3(6),635-641.

Bolmont, B.,Thullier, F.,Abraini, J. H.(2000).Relationships between mood states and performances in reaction time, psychomotor ability, and mental efficiency during a 31-day gradual decompression in a hypobaric chamber from sea level to 8,848 m equivalent altitude.Physiology and Behavior.71(5),469-476.