The purpose of this study is to investigate the effect of traditional Chinese medicine (TCM) syndrome type of patients with metabolic syndrome on their quality of life. This cross-sectional correlational study used purposive sampling to enroll a total of 161 patients at the outpatient clinic of metabolism in a certain regional teaching hospital in the northern Taiwan as the subjects. The research results showed that: Quality of life had a significant effect on different TCD syndrome types (p<0.05) (except for yin deficiency constitution).