The world economic is in a slump since U.S. subprime mortgage crisis in 2008, economic problems emerge continuously around the world. ”200% business opportunity” was the cover story of Business Weekly No. 1288 which reported instead of the depression, hotel industry is still growing in this crisis. It is not enough only providing excellent service experience in the competitive business environment. How to create differentiation advantage? Hotel industry can try to proceed from the level of customer relationship and mental satisfaction. The purpose of this research is to explore the relationship between service experience, relationship quality and well-being. Data gathered from online questionnaire platform. Analysis results show that: (1) service experience has significant positive influence on relationship quality; (2) relationship quality has significant positive influence on well-being; (3) service experience has significant positive influence on well-being.