Despite the considerable literature on Confessions, the crucial role of the doctrine of creatio ex nihilo in this classical work has not been sufficiently explored. This paper will argue that the doctrine of creation from nothing plays a fundamental, unifying role in Confessions, in that it provides the theological basis for the underlying theme of the book, namely the relation between God and creatures. Specifically, not only does this doctrine undergird Augustine's understanding of God's simultaneous transcendent and immanent relation to creatures, but his distinctive interpretation of creatio ex nihilo is foundational to his narrative of the soul's journey back to God, a microcosm of the whole creation's movement toward God.