On July 31, 2014, a devastating petrochemical gas explosion occurred in Kaohsiung, Taiwan. Our hospital was immediately designated as the mass injuries emergency response center due to its geographic proximity to the site of the explosion. A total of 227 hospital personnel were called on duty immediately, including 26, 49, and 75 physicians, nurses, and administrators with other on-duty staff, respectively. Our hospital received the most patients in Kaohsiung city—68 wounded patients within the first two hours. The patients presented with combinations of burns, blunt force trauma, fractures, lacerations, and ruptured viscera. Our hospital was able to mobilize our staff in a short amount of time to help with disaster relief and the timely and proper treatment of most of the patients. The purpose of this article was to describe the disaster response experience to serve as a reference for other hospitals dealing with disaster medicine.