In this study, high school teachers who are currently serving in Taichung City are used as research objects in 2021. Research tools include "Sports Participation Scale" and "Chronic Fatigue Syndrome Scale". A total of 395 valid questionnaires were obtained using questionnaire surveys, and the data obtained from the study were verified by statistical methods such: single factor variance analysis and regression analysis. This study has the following conclusion: the degree of exercise participation can effectively predict the improvement of chronic fatigue syndrome, and has a positive result.