The purpose of this study is to explore the innovation of the curriculum and instruction for general education. To begin with, the researcher outlines the revolutionary ideas and related researches of curriculum and instruction for general education. There are six areas of the curriculum and the instruction for general education including the lecturing curriculum and instruction, the core curriculum and instruction, the curriculum and instruction of action learning, the curriculum and instruction of problem-based learning, web-based instruction, and team teaching. Secondly, the researcher addresses the implementation of the new curriculum and instruction for general education in Cheng Shiu University. Finally, some reflections are discussed in order to improve the curriculum and instruction of general education for Cheng Shiu University.