In 1993, the first reports of a new adverse effect defined as transient neurological symptoms (TNS), was described in patients recovering from spinal anesthesia with hyperbaric 5% lidocaine in the lithotomy position who postoperatively experienced aching and pain in the buttocks, thighs or lower extremities without associated with neurologic deficits or laboratory abnormalities. The symptoms can develop within 24 hours after a full recovery from ordinary uneventful spinal anesthesia. However, they are infrequently caused by lumbar epidural anesthesia and analgesia. We present a case of TNS caused by lumbar epidural anesthesia and analgesia in a young female adult receiving major abdominal surgery. We also review the etiology, pathophysiology, diagnostic criteria, and treatment of TNS.