Andrographolide Induced Acute Kidney Injury: A Case Report

穿心蓮內酯引發急性腎損傷：病例報告

謝靜蓉(Ching-Jung Hsieh)

《南臺灣醫學雜誌》 16卷2期 (2020/12) Pp. 94-98

https://doi.org/10.6726/MJST.202012_16(2).0005

摘要

This is the first report of oral form Chinese medicine andrographolide induced acute kidney injury. The present study reports a 51 years old male Taiwanese patient with type 2 diabetes, who had well blood glucose control and no history of chronic kidney disease or proteinuria. He presented with 2 episodes of rapid increased serum creatinine following 2 times of one week of andrographolide (2000-3000 mg/day) taking for fatty liver and decreasing libido. Following 1 week of hospitalized intravenous hydration of normal saline therapy, the patient's serum creatinine and urea nitrogen decreased to within normal ranges respectively. The presentation, clinical course, and prognosis of andrographolide induced acute kidney injury are discussed herein to highlight the importance of early and correct diagnosis and treatment.

關鍵字

androrapholide ； acute kidney injury ； Chinese medicine

並列摘要

此報告為第一篇口服中藥穿心蓮內酯（andrographolide）引發急性腎損傷的個案報告。病患為51歲男性，過去並無慢性腎疾病或尿蛋白的二型糖尿病患，並且血糖皆控制於標準值。因為深信穿心蓮可以減少脂肪肝及改善性功能，前後兩次在服用一週（每日2000至3000毫克）穿心蓮之後發生急性腎損傷。然而經由一週的住院接受大量生理食鹽水輸液治療之後，肌肝酸及尿素氮皆回復正常。在此提醒大家對穿心蓮引發之急性腎損傷的關注並回顧文獻對穿心蓮的治療療效及引發急性腎損傷副作用的探討。

並列關鍵字

穿心蓮內酯 ； 急性腎損傷 ； 中草藥