The Effects of Fermented Wheat Germ Extract on Cancer-Related Fatigue

發酵小麥胚芽萃取物對癌因性疲憊的影響

劉明宜(Ming-Yi Liu) ； 胡淑惠(Shu-Hui Hu) ； 劉素芬(Su-Fen Liu) ； 陳美珠(Mei-Ju Chen) ； 林家義(Ka-Ee Ling)

《南臺灣醫學雜誌》 17卷2期 (2021/12) Pp. 80-88

https://doi.org/10.6726/MJST.202112_17(2).0003

摘要

Objective: This study aimed to investigate the effects of fermented wheat germ extract for improving fatigue in patients receiving chemoradiotherapy. Methods: The study conducted with outpatient cancer patients from the oncology department. Institutional Review Board evaluation and approval were obtained before conducting the study. Using a clinically prospective randomized study design, fermented wheat germ extract was administered to the experimental group (n = 11). The control group received routine nutritional care (n = 12). All the patients (n = 23) received dietary counselling and advice. EORTC QLQ-C30 and EORTC QLQ-FA12 were used to assess the quality of life and the impact of cancer-related fatigue. The nutritional status was assessed using the Patient Generated-Subjective Global Assessment (PG-SGA), and biochemical data on indicators was related to the nutritional status. Results: The results showed that post-intervention PG-SGA scores and QLQ-FA12 scores were significantly lowered compared with the pre-intervention scores. In both the groups, the nutritional status and degree of cancer-related fatigue were significantly improved. The QLQ-C30 score was significantly lower on the symptom scale, indicating a significant improvement in clinical symptoms or side effects. In the global health status, the scores were increased significantly, indicating a good quality of life, and the intervention group demonstrated significant improvement compared to the control group (p = 0.034). Conclusion: The fermented wheat germ extract is an effective intervention to improve appetite in cancer patients receiving chemotherapy, and to reduce the symptoms of cancer-induced fatigue and improve the quality of life.

關鍵字

cancer related fatigue ； fermented wheat germ extract ； nutritional care

並列摘要

目的：本研究探討發酵小麥胚芽萃取物對接受化放療病人改善疲憊的作用。方法：研究針對腫瘤科門診病人，研究採隨機對照試驗設計，分為發酵小麥胚芽萃取物實驗組（n=11），以及接受一般營養品的對照組（n=12），所有患者（n=23）均接受相同的飲食諮詢和建議。使用歐洲癌症治療與研究組織QLQ-C30和QLQ-FA12量表評估營養介入前後之生活品質與癌症相關疲勞的嚴重程度和影響，並收集分析病人主觀整體營養評估表（PG-SGA）和營養狀況相關指標生化檢驗數據。結果：結果顯示，介入後的PG-SGA、QLQ-FA12分數，兩組均顯著低於介入前的分數，顯示營養狀況和與癌症相關的疲憊程度均得到改善，兩組的QLQ-C30評分也顯示臨床症狀或副作用有明顯改善。而在整體健康狀況評估，實驗組則比對照組有顯著改善（p=0.034），每日熱量及蛋白質攝取量均有顯著增加。結論：小麥胚芽發酵萃取物是一種有潛力的營養品，可提高接受化療的癌症患者的食慾，並減輕癌症引起的疲勞症狀並改善生活品質。

並列關鍵字

癌因性疲憊 ； 小麥胚芽發酵萃取物 ； 營養照護