The Internet technology has brought major changes to the way business is conducted today. Many terms have been coined to represent the electronic concepts and applications such as e-Business and e-Commerce. These terms are commonly used to represent the transformation of business processes and transactions. In Malaysia, the e-Business adoption has not only captured the interest of large organizations but has also been acknowledged and adopted by small, medium and micro sized enterprises. Implementing e-Business requires significant changes in a company's structure, culture, strategy, procedures and responsibilities. However, the challenges do not stop people from venturing into this new business concept. A study is conducted to look into e-Business potential for micro sized businesses that operate from home in Malaysia. In this study both qualitative and quantitative methods are used. This paper reviews the issues pertaining to e-Business and home-based business, describes the methodology and reports the early findings from the study