This research creates the cause-effect model of learning orientation, knowledge management mechanism and organization performance. This research proposes the pre-variables of ”organization performance” are those aspects, learning orientation divided to three concept ”Commitment to Learning”, ”Shared Vision”, ”Open-Mindedness”, and intervening variable is ”Knowledge Management Mechanism” etc. Through empirical example analysis, this research can get most of every variable, and understand the variable and variable existence relation and intensity of one. The result of this study is helpful High-Tech industries factory according to different industries and companies to shape their own management strategies.