Portland cement has widely been used to improve weak and wet subgrade soils in highway construction. Its effectiveness on enhancing subgrade soils, however, depends on multiple factors. This paper aims at building a reliable cement-treated subgrade layer by checking its Unconfined Compression Strength (UCS) and developing a guideline for selecting appropriate cement content based on the field moisture content of subgrade soils. A series of laboratory tests were conducted on two typical low-plasticity subgrade soils encountered in Louisiana, which examine the possible correlation among UCS, molding moisture content, dry unit weight, and water-cement ratio. Based on these laboratory testing results, a tentative procedure to construct a reliable cement-treated subgrade layer is proposed.