Development of Single-side Magnet Array for Super Paramagnetic Nano-particle Targeting

Permanent magnets are interesting for the use in magnetic drug targeting devices. The magnetic fields and forces with distances from magnets have limited the depth of targeting. Producing greater forces at deep depth by optimally designed magnet arrays would allow treatment of a wider class of patients. In this study, we present a design of a permanent magnet array for deep magnetic capture of super paramagnetic iron oxide nano-particles, which consists of an array of 3 individual bar permanent magnet positioned to achieve a reasonably magnitude magnetic field and its gradient within a deeply region. These configurations were simulated with two-dimensional finite-element methods. The super paramagnetic iron oxide nano-particles were adopted Fe_3O_4 particles with diameter 40 nm by chemical co-precipitation method. Performance factors were defined to relate magnetic field force with mass. The field strength and gradient were measured by a Hall probe and agreed well with the simulations.

並列關鍵字

Halbach-like arrays ； magnetic drug targeting ； magnetostatic application ； super paramagnetic iron oxide nano-particles

國際替代計量

全文下載

主題瀏覽