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Effects of Aqueous and Methanol Extracts of Zingiber officinale on the Haematological Profile in Schistosoma haematobium-Infected Mice
並列摘要
The aim of the study was to evaluate the immunomodulating effects of aqueous and methanol extracts of Zingiber officinale on the haematological profile in Schistosoma haematobium - infected mice.The weight and haematological profiles of Schistosoma haematobium - infected mice were assessed to evaluate the immunomodulating effects of aqueous and methanolic extracts of Zingiber officinale at post-infection and post-treatment. There was a non-significant decrease (p＞0.05) in the weight of mice in all the groups. However, there was a significant increase (p＜0.05) in the total white blood cell counts, neutrophils and lymphocytes for group I (S. haematobium - infected mice treated with 9.5mg/kg aqueous extract of Zingiber officinale). In group II - (S. haematobium - infected mice treated with 87mg/kg methanolic extract of Zingiber officinale), there was significant increase (p＜0.05) in the haemoglobin level and white blood cells. Methanolic extract of Zingiber officinale has better anti-anaemic effect than the aqueous extract of Zingiber officinale . There was no relationship between the level of eosinophils and the treated mice. No significant change in the haematological indices was observed in the group which was administered the standard drug- Praziquantel (PZQ). The immunomodualting effects of aqueous and methanol extracts of Zingiber officinale when compared to PZQ are promising in immunosuppressed Schistosoma haematobium- infected mice. Fractionation of the crude extract of Zingiber officinale may further identify the bioactive components required for treatment of urinary schistosomiasis.
延伸閱讀
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