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Effect of Aqueous-Methanolic Stem Bark Extract of ＂Acacia polyacantha＂ on Blood Glucose Levels on Normoglycemic Wistar Rats
並列摘要
This study was carried out to investigate the blood glucose reducing effect (hypoglycemic effect) of stem bark extract of ＂Acacia polyacantha＂ on normal wistar rats over a 24 h period. Three groups of previously fasted wistar rats, with each group made up of 5 rats each were administered with 100, 200 and 400 mg/kg p.o of aqueous methanolic stem bark extract of ＂A. polyacantha＂. The hypoglycemic effect of A . polyacantha stem bark aqueous methanolic extract was compared with that of Metformin (250 mg/kg) in fasted normal rats. Following treatment, relatively moderate to high doses of ＂A. polyacantha＂ (100, 200 and 400 mg/kg p.o.) produced a dose-dependent, significant reduction (p＜0.05) in blood glucose levels of fasted normal rats. The three doses of the extract did not significantly alter the blood glucose levels after 2 h of extract administration. After 8 and 16 h of extract administration at a dose of 200 mg/kg significantly (p＜0.05) decreased the blood glucose levels when compared to control, while the dose of 400 mg/kg significantly decreased the blood glucose levels after 4, 8 and 16 h of extract administration when compared with the control group. The Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, triterpenoids, anthraquinones, steroids and saponins. The median lethal dose (LD_(50)) in rats was calculated to be 3807.9 mg/kg body weight. In conclusion the aqueous methanolic extract of ＂Acacia polyacantha＂ possesses hypoglycemic activity in normoglycemic rats.
延伸閱讀
- Okpanachi, A., Adelaiye, A., Dikko, A., Kabiru, M., Mohammed, A., & Tanko, Y. (2010). Evaluation of the Effect of Aqueous-methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels of Alloxan Induced Diabetic Wistar Rats. International Journal of Animal and Veterinary Advances, 2(3), 59-62. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201007-201009060078-201009060078-59-62
- Goji, A., Dikko, A., Bakari, A., Mohammed, A., Ezekiel, I., & Tanko, Y. (2009). Effect of Aqueous-ethanolic Stem Bark Extract of Commiphora Africana on Blood Glucose Levels on Normoglycemic Wistar Rats. International Journal of Animal and Veterinary Advances, 1(1), 22-24. https://www.airitilibrary.com/Article/Detail?DocID=20412908-200907-201008160039-201008160039-22-24
- Spencer, C. N., Sunday, J. J., Usunomena, U., Udoka, N., Akintola, A. A., Ehiremen, O. I., & Kingsley, O. (2011). Effects of Aqueous and Ethanolic Extract of ＂Vernonia amygdalina＂ Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats. Current Research Journal of Biological Sciences, 3(5), 504-508. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201109-201512280013-201512280013-504-508
- Lartey, N., Anane, H. A., Ofori, E., Antwi, S., Larbi, J. A., Ayertey, F., & Okine, L. (2021). Antidiabetic activity of aqueous stem bark extract of Annickia polycarpa in alloxan-induced diabetic mice. Journal of Traditional and Complementary Medicine, 11(2), 109-116. https://doi.org/10.1016/j.jtcme.2020.02.001
- Eze, E. D., Mohammed, A., Musa, K. Y., Malgwi, I. S., & Mohammed, R. K. (2012). Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels on Normoglycemic Wistar Rats. International Journal of Animal and Veterinary Advances, 4(1), 49-52. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201202-201507210031-201507210031-49-52