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Antidiabetic activity of aqueous stem bark extract of Annickia polycarpa in alloxan-induced diabetic mice
摘要
Background and aim: There is a growing need to develop new drugs for type II diabetes mellitus (DM) from plant sources due to the high cost and adverse side effects of current drug therapies. To this end, the antidiabetic activity of aqueous stem-bark extract of A. polycarpa (APE) in alloxan-induced diabetic ICR mice was investigated. Experimental procedure: The effect of APE (20, 100 and 500 mg/kg), glibenclamide and metformin as positive controls, were determined over 4 weeks on fasting blood glucose (FBG). An oral glucose tolerance test (OGTT) was also conducted. The effects of these treatments on the morphology of the pancreas were assessed. In addition, phytochemical constituents and antioxidant properties of APE were determined. Results and conclusion: APE, like glibenclamide and metformin, showed significant hypoglycaemic effect. The OGTT supported the hypoglycaemic effect. The destroyed pancreatic beta-cells in diabetic control mice were restored to normal by APE or drug treatment. APE showed antioxidant activity by scavenging DPPH free radicals; this may be due to the presence of phenolic compounds, particularly flavonoids. Thus, APE may act by restoring pancreatic beta-cell integrity through mopping of reactive oxygen species (ROS) associated with the diabetic state, and thereby improving pancreatic function and consequently, the lowering of FBG levels. These findings provide ample evidence to validate the traditional use of A. polycarpa in the management of DM.
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- Komeili, G., Hashemi, M., & Niafar, M. B. (2016). Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats. Cholesterol, 2016(), 30-35. https://doi.org/10.1155/2016/7389864
- Mohan, Y., Jesuthankaraj, G. N., & Thangavelu, N. R. (2013). Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats. Advances in Pharmacological Sciences, 2013(), 143-151. https://doi.org/10.1155/2013/716073
- Adeneye, A. A., Awodele, O., Aiyeola, S. A., & Benebo, A. S. (2015). Modulatory potentials of the aqueous stem bark extract of Mangifera indica on carbon tetrachloride-induced hepatotoxicity in rats. Journal of Traditional and Complementary Medicine, 5(2), 106-115. https://doi.org/10.1016/j.jtcme.2014.11.001
- Mordi, J. (2012). Antidiabetic Potential of the Aqueous Leaf Extract of Cnidoscolus aconitifolius on Streptozotocin (STZ) Induced Diabetes in Wistar Rat Hepatocytes. Current Research Journal of Biological Sciences, 4(2), 164-167. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201203-201512280016-201512280016-164-167
- Owolabi, O. A., James, D. B., Anigo, K. M., Iormanger, G. W., & Olaiya, I. I. (2011). Combined Effect of Aqueous Extracts of Phyllathus amarus and Vitex doniana Stem Bark on Blood Glucose of Streptozotocin (STZ) Induced Diabetes Rats and Some Liver Biochemical Parameters. British Journal of Pharmacology and Toxicology, 2(3), 143-147. https://www.airitilibrary.com/Article/Detail?DocID=20442467-201108-201507070013-201507070013-143-147