- 期刊
- OpenAccess
Effects of Dietary Furundu (Fermented Hibiscus sabdariffa Seed) Supplementation on the Performance, Some Blood and Serum Parameters and Histopathology of Wistar Rats
並列摘要
The present study was conducted to obtain information on the effects of various dietary doses of the fermented Hibiscus sabdariffa seed (Furundu) on Wistar rats. Emphasis was put on changes on growth, lesions, alteration in hematology and serobiochemical constituents and histopathology of treated rats. Fermented Hibiscus sabdariffa seed product (Furundu) was fed to Wistar rats at 10, 15 and 20%, respectively of the standard diet for 12 weeks. Incorporation in the diet of the three doses of both was toxic but not fatal. Depression in growth and hepatonephrotoxicity were observed in rats that had been given 10, 15 and 20% Furundu, respectively for 12 weeks. These findings were accompanied by leukocytosis, macrocytic normochromic anaemia in rats fed on 20% Furundu and macrocytic hypochromic, normocytic hypochromic anaemia in those fed on 10 and 15% Furundu respectively, in addition to alterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activity and albumin, globulin, bilirubin and cholesterol concentrations. At the end of the experimental period (12 weeks), the total protein of all the test groups and the globulin concentration of group 2 fed on 15% Furundu decreased significantly (p＜0.05), albumin concentration of all the test groups and the urea concentration of group 3 fed on 15% Furundu remained unchanged. Histopathological examination showed Fatty cytoplasmic vacuolation of the centrilobular hepatocytes and lymphocytic infiltration, desquamation of the intestinal epithelium and intestinal congestion were noticed in rats fed on 20% Furundu. Fermented Hibiscus sabdariffa seed product Furundu is considered enterohepatonephrotoxic to Wistar rats at dietary levels of 10, 15 and 20%, respectively.
延伸閱讀
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