Anti-ulcerogenic and Anti-inflammatory Activity of ＂Cissus multistriata＂ Extract in Experimental Animals

Omale James ； Eleojo Berikisu Ojogbane ； Okpachi Christopher Abbah ； Moses Oluwatobi Tehinse

《British Journal of Pharmacology and Toxicology》 4卷3期 (2013/06) Pp. 74-79

並列摘要

This present study was undertaken to evaluate the anti-ulcerogenic and anti-inflammatory properties of methanol extract from the leaves of ＂Cissus multistriata＂. Gastric ulcer and inflammation were induced in experimental animals using ethanol and acetic acid respectively. Anti-ulcerogenic action of ＂C. multistriata＂ was evaluated in albino rats at doses of 30, 50 and 100 mg/kg body weight. ＂Cissus multistriata＂ showed gastro-protective action in the groups and the protection was dose dependent and comparable to the standard drug (Omeprazole) used. The mechanism involved in the gastro- protective effect of ＂C. multistriata＂ may be related to the mucosal protector factors, such as Nitric Oxide (NO) and Sulfhydryl (SH) compounds. Anti-inflammatory activity was also studied on the plant using the paw edema method on different groups of rats. The methanol extract of ＂C. multistriata＂ exhibited potent anti-inflammatory activity at 150 mg/kg b.w at 4 h after administration to group 4 when compared with reference standard drug (Indomethacin). Group 2 had 72% inhibition of edema as compared to 55% inhibition offered by the extract at 150 mg/kg, thus showing a great effect at higher doses. From this study, it is clear that ＂C. multistriata＂ leaf extract had significant anti-ulcer activity in animal model. It also demonstrated high antiinflammatory potential at 150 mg/kg b.w. These observed pharmacological activities therefore, provide scientific support for the ethno-medicinal uses of this plant.

並列關鍵字

Anti-inflammatory ； anti-ulcerogenic ； ＂Cissus multistriata＂ ； experimental animals