Immunomodulatory Effects of Lactic Acid Bacteria in Patients with Perennial Allergic Rhinitis

乳酸菌對過敏性鼻炎患者的免疫調節作用

王銘甫(Ming-Fuu Wang) ； 許清祥(Ching-Hsiang Hsu)

《童綜合醫學雜誌》 2卷1期 (2008/06) Pp. 9-18

https://doi.org/10.29838/TMJ.200806.0002

摘要

Background: Lactic acid bacteria can alleviate the disease severity of atopy and, prevent the development of allergies, possibly via their ability to modulate the immune response.Purpose: We aimed to examine the clinical efficacy, safety, and immunological effects of Lactobacillus paracasei-33 (LP-33) in patients with mite-induced perennial allergic rhinitis.Methods: In this randomized, double blind, placebo-controlled study, 57 subjects were assigned to the LP-33 group (n = 41) and the placebo group (n = 16), based on consumption of yogurt with or without LP-33 for 12 weeks. Relative changes of symptom scores after intervention were used for primary outcome measure. We also assessed the changes of immunological parameters, including interferon (IFN)-γ, interleukin (IL)-4, and total serum immunoglobulin (Ig) E at enrolment and after 12 weeks of treatment.Results: Consumption of LP-33 fortified fermented milk demonstrated significantly greater improvement in symptoms (P ＜ 0.05) during the intervention and follow-up period. LP-33-treated subjects had a significant increase in IFN-γ level (33.77±6.93 pg/mL vs. 41.05±8.75 pg/mL, P = 0.001) and reduction in IgE level (732.53±229.20 IU/mL vs. 579.96±125.99 IU/mL, P = 0.032). No subjects reported any adverse side effects.Conclusion: Patients who consumed LP-33-fortified fermented milk had significantly less symptoms of allergic rhinitis. The mechanisms were probably due to the immunomodulatory effects of probiotics. This may further provide a novel and safe approach to perennial allergic rhinitis.

關鍵字

益生菌 ； 過敏性鼻炎

並列摘要

Background: Lactic acid bacteria can alleviate the disease severity of atopy and, prevent the development of allergies, possibly via their ability to modulate the immune response.Purpose: We aimed to examine the clinical efficacy, safety, and immunological effects of Lactobacillus paracasei-33 (LP-33) in patients with mite-induced perennial allergic rhinitis.Methods: In this randomized, double blind, placebo-controlled study, 57 subjects were assigned to the LP-33 group (n = 41) and the placebo group (n = 16), based on consumption of yogurt with or without LP-33 for 12 weeks. Relative changes of symptom scores after intervention were used for primary outcome measure. We also assessed the changes of immunological parameters, including interferon (IFN)-γ, interleukin (IL)-4, and total serum immunoglobulin (Ig) E at enrolment and after 12 weeks of treatment.Results: Consumption of LP-33 fortified fermented milk demonstrated significantly greater improvement in symptoms (P ＜ 0.05) during the intervention and follow-up period. LP-33-treated subjects had a significant increase in IFN-γ level (33.77±6.93 pg/mL vs. 41.05±8.75 pg/mL, P = 0.001) and reduction in IgE level (732.53±229.20 IU/mL vs. 579.96±125.99 IU/mL, P = 0.032). No subjects reported any adverse side effects.Conclusion: Patients who consumed LP-33-fortified fermented milk had significantly less symptoms of allergic rhinitis. The mechanisms were probably due to the immunomodulatory effects of probiotics. This may further provide a novel and safe approach to perennial allergic rhinitis.

並列關鍵字

Probiotic ； Allergic rhinitis ； Lactobacillus paracasei