- 期刊
- OpenAccess
Apple Polyphenols Decelerate Acetaminophen-Induced Oxidative Stress
蘋果多酚在動物模式中延緩acetaminophen誘導的氧化壓力
摘要
背景及目的：Acetaminophen（AAP）誘導氧化壓力會使細胞死亡而引起肝臟損傷，先前研究顯示蘋果多酚（apple polyphenol, AP），具有抗氧化力，因此本研究將探討在動物模式中，AAP誘導氧化壓力時，AP的作用為何。方法：BABL/c小鼠以管餵方式給予AP（100, 200, 300 mg kg^(-1)）2周，之後以腹腔注射給予1000 mg kg^(-1)的AAP。結果：預處理AP降低肝臟脂質過氧化、增加catalase活性及glutathione含量。討論：AP被證明可以保護肝臟免於AAP誘導的損傷，而此機轉可能包括了降低氧化壓力。
並列摘要
Background and purpose: Acetaminophen (AAP)-induced oxidative stress can cause cell death and consequent liver damage. Apple polyphenols (APs) are known to exert antioxidative effects. In this study, we investigated the effect of AP on AAP-induced oxidative stress in mouse liver injury.Methods: BABL/c mice were orally fed with AP (100, 200, 300 mg kg-1) for two weeks, and then injected with 1000 mg kg^(-1) of AAP. Results: Pretreatment with AP decreased the level of lipid peroxidation and increased catalase activity and glutathione levels. Discussion: AP demonstrably protects the liver from AAP-induced injury, possibly by a mechanism that reduces oxidative stress.
延伸閱讀
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