Re-expansion pulmonary edema (RPE) is a rare complication of treatment for pleural effusion and pneumothorax. It typically manifests as edema within the lung that has recently been re-expanded. The condition generally occurs unexpectedly and dramatically, either immediately or within 24 h. Its clinical manifestations are varied, ranging from chest X-ray findings alone in asymptomatic patients to severe cardiorespiratory insufficiency. Here we present a case on unilateral RPE after draining a left-sided massive pleural effusion. In addition, several recent research articles on the pathophysiology and treatment of RPE are discussed.