Acute scrotal swelling may be caused by the extension of a pancreatic collection or abscess through the inguinal canal into the groin area and is a rare complication of acute pancreatitis. Although this complication has a low incidence, we must consider this condition as it may be misdiagnosed as other more common pathologies of a swollen scrotum such as testicular hydrocele, orchiepididymitis, testicular torsion, inguinal hernia, and testicular tumor and may result in inappropriate or delayed treatment. Herein, we describe a case of right scrotal swelling caused by severe acute pancreatitis in a 52-year-old man. Computed tomography was helpful in the diagnosis. Typical imaging demonstrated peripancreatic fluid through the inguinal canal to the right scrotum and confirmed the diagnosis by aspirated scrotal fluid with elevated lipase levels.