The purpose of this study was to investigate the learning effects of the Last-Mile Curriculum on the professional competence, professional commitment, and sense of work excitement of college nursing students using both quantitative and qualitative methods. The purposive sampling consisted of 114 nursing students from a four-year technology college in Northern Taiwan. Three quantitative instruments were used, including self-administered questionnaires of the nursing professional competence scale, the nursing professional commitment scale, and the sense of work excitement scale for data collection before and after the whole Last-Mile clinical practice curriculum. Reflection journals were also used as qualitative supplements for this study. The results showed positive effects on the implementation of the Last-Mile Curriculum on the professional competence, professional commitment, and sense of work excitement of nursing students. Therefore, the results of this study provide useful references for future course planning of nursing education.