This study aimed to analyzing syntactic patterns of simple sentences and investigating the effects of multimedia computer situated instruction on the performance of syntactic patterns of simple sentences for students with intellectual disability in vocational senior high department of National Taichung School for Students with Hearing Impairments. The experimental instruction program of multimedia computer situated learning was finished in a semester. The multiple-probe across behavior design was utilized in the study and the data were analyzed by graphic display and visual analysis. The results of this study indicate that 90% participants with intellectual disability use narrative sentences, about 70% participants with intellectual disability use yes-no sentences, about 30% participants with intellectual disability use expressing sentences, and about 20% participants with intellectual disability use judgmental sentences. Furthermore, the multimedia computer situated instruction immediately enhance, and maintain the performance of syntactic patterns of simple sentences for students with intellectual disability in vocational senior high school. According to the results, some suggestions and further researches were recommended.