Eight Probiotics Are Effective in Lowering Serum Lipids

Wen-Hong Wang ； Yung-Wei Chiu ； Shao-Hsuan Kao ； Wei-Jen Ting ； Chih-Yin Hsu ； Hung-Hui Cheng ； Hsueh-Hui Lee ； Kuanghui Hsieh ； Jer-Yuh Liu ； Jin-Ming Hwang

《Adaptive Medicine》 8卷1期 (2016/03) Pp. 1-5

https://doi.org/10.4247/AM.2016.ABG131

並列摘要

Many types of lactobacilli (LBs) can be used to decrease serum lipid levels, and multi-strain LB cultures are beneficial for health. In the present study, eight probiotics including four LBs (L. acidophilus, L. casei, L. paracasei, and L. rhamnosus) were selected to test their combined ability to decrease the serum lipid levels of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet. This experiment involved the oral injection of a set ratio of probiotics into hamsters that were given high-lipid and high-cholesterol diets. The levels of serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerols (TGs), and total cholesterol (TC) increased in the group given high-cholesterol and high-fat diets (110 ± 12, 241 ± 97, 586 ± 218, and 546 ± 303 mg/dl, respectively) compared with those of the control group (51 ± 8, 19 ± 5, 75 ± 15 and 104 ± 42 mg/dl, respectively). When treated with various doses of probiotics (200, 400, and 800 mg/kg), similar to the rosuvastatin-cotreated group, the hamsters presented different levels of recovery of serum LDL-C, TG, and TC levels in a dose-dependent manner. Therefore, the eight probiotics have the potential to decrease serum lipid levels in hamsters.

並列關鍵字

cholesterol ； probiotics ； triglycerols