Effects of Environmental Estrogen on Lung Cancer Cell

Chia-Hung Sun ； Paulus S. Wang

《Adaptive Medicine》 11卷1期 (2019/03) Pp. 7-11

https://doi.org/10.4247/AM.2019.ABJ225

摘要

Environmental estrogen is known as xenoestrogen because its structure and function are similar to that of natural estrogen. It is widely used in our life including pesticides, detergents, food preservatives, oral contraceptives, plastic products, and vehicle fuel. However, these substances containing estrogen are released into wastewater treatment plants, soils, and air without further dilution. As a result, the high concentration of this endocrine disruptor impacts ecological system and has been gradually paid more attention. In recent decades, environmental estrogen has been reported to be associated with reproductive disorders, inflammatory responses, and the prevalence of cancer. This study presented the common routes of environmental estrogen entering in to human body which contribute to lung cancer development. Both estrogen receptors (ER) α and β were activated via xenoestrogenic way first wherein epidermal growth factor receptor (EGFR) was triggered. The following downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phosphoinositide 3-kinase and protein kinase B (PI3K/AKT) pathways were activated. Finally, the transcription of target genes modulates the serial translation to promote lung cancer cell proliferation, migration, angiogenesis, and metastasis. According to the previous investigations, we summarized that environmental estrogen stimulated lung carcinogenesis via estrogenic pathway as well as up regulation of the sequential EGFR/ERK/AKT signals.

關鍵字

AKT ； EGFR ； environmental estrogen ； ER ； ERK