Association Study of Dopamine β-Hydroxylase Gene with Methamphetamine Psychosis

Yuko Okahisa ； Hiroshi Ujike ； Manabu Takaki ； Yutaka Mizuki ； Shinji Sakamoto ； Won Mujun ； Naoki Kondo ； Nobuya Naruse ； Kumi Aoyama-Uehara ； Nakao Iwata ； Masaomi Iyo ； Ichiro Sora ； Norio Ozaki ； Yosuke Uchitomi

《Journal of Drug and Alcohol Research》 3期 (2014/12) Pp. a1-6

https://doi.org/10.4303/jdar/235792

並列摘要

Dopamine is a key molecule in the pathophysiology of methamphetamine (METH) psychosis. We examined the association between METH psychosis and the dopamine β-hydroxylase (DBH) gene, which modulates dopaminergic cascades. Six polymorphisms, rs1989787, rs1611115, rs1108580, rs5320, rs1611125, and rs6271, of the DBH gene were genotyped. These polymorphisms were not associated with METH-seeking behaviors of patients with METH psychosis (N=216) or healthy controls (N=328), but rs1611125 affected one of the clinical phenotypes of METH psychosis. Individuals with the G/G homozygote of rs1611125 had a significant risk for spontaneous relapse of METH psychosis (P=.02, odds ratio=2.2). In haplotype analyses, rs1108580-rs5320-rs1611125 was revealed to be associated with METH psychosis (P=.01). Having G-Ala-G was a significant risk factor, while A-Thr-A was a protective factor for METH psychosis (odds ratio were 9.9 and 0.16, resp.). Our present findings indicated that the DBH gene may play an important role in METH psychosis.

並列關鍵字

substance abuse ； methamphetamine ； dopamine β-hydroxylase ； case-control association