以氣相層析質譜法同時分析化粧品中禁用鄰苯二甲酸酯類成分之檢驗方法研究

本研究係利用氣相層析質譜法建立一簡單、快速的方法能同時分析化粧品中Benzylbutyl phthalate （BBP）、Dibutyl phthalate （DBP）、Bis （2-ethylhexyl） phthalate （DEHP）、Bis（2-methoxyethyl） phthalate （DMEP）、Diisopentyl phthalate （DIPP）、Di-n-pentyl phthalate（DnPP）及Di-n-octyl phthalate （DnOP）等七種禁用鄰苯二甲酸酯類成分。檢體以甲醇溶解並定容離心後，以氣相層析質譜儀進行分析，層析管柱使用被覆5% phenyl - 95%methylpolysiloxane之HP-5MS毛細層析管（30 m × 25 mm, 0.25 mm），並採用氦氣為移動相氣體，以電子撞擊游離法偵測。七種成分標準曲線之線性範圍為0.5-40 μg/mL，線性回歸之判定係數（r^2）介於0.9975-0.9996之間，同日內及異日間試驗之相對標準偏差均小於5.8%。添加不同濃度之標準品於空白檢體中，回收率介於84.8-115.0%，相對標準偏差均小於7.6%。最低定量濃度則均小於5.0 ppm。應用本研究所建立之方法檢測市售化粧品共131件，結果均符合行政院衛生署97年12月25日公告化粧品中鄰苯二甲酸酯類成分之總殘留量不得超過100ppm。

關鍵字

鄰苯二甲酸酯類；氣相層析質譜；化粧品

並列摘要

A gas chromatography-mass spectrometry method was developed for the simultaneous determination of seven phthalates (BBP, DBP, DEHP, DMEP, DIPP, DnPP and DnOP) in cosmetics. Samples were analyzed using a capillary column (HP-5MS, 30 m × 25 mm id, 0.25 mm) with the carrier gas He. Regression equations of seven standard curves revealed the coefficients of determination, r^2, between 0.9975-0.9996. The relative standard deviations of seven components for intraday and interday analyses were less than 5.8%. The average recoveries of five components ranged from 84.8 to 115.0%. The relative standard deviations of average recoveries were less than 7.6%. The limits of quantitation in cosmetics were less than 5.0 ppm. One hundred and thirty-one samples were randomly collected from cosmetics stores, drug stores or pharmacies by local health personnel in Taiwan area from May to September, 2011. These samples were analyzed for seven kinds of phthalate esters by the above method. The result showed that all were below than the announced level of 100 ppm by Department of Health.

並列關鍵字

phthalates ； GC/MS ； cosmetics

國際替代計量

以氣相層析質譜法同時分析化粧品中禁用鄰苯二甲酸酯類成分之檢驗方法研究

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