In order to ensure the quality of the marketed antidiabetic agents and hypnotic oral dosage form preparations, fifty six samples of metformin hydrochloride and zolpidem tartrate preparations were collected from hospitals, clinics, pharmacy stores and pharmaceutical manufacturers in Taiwan by local health authorities from January to September 2014. Samples were analyzed by the methods as described in the Ch. P. 7 / USP 36 with authorized specifications. The analysis items included appearance, average weight, identification, assay, dissolution, uniformity of dosage unit and organic impurities. Only one sample failed on the specification of dissolution, all the others met the compendia requirements.