文獻回顧：四環素光化學研究

四環素類化合物（tetracyclines, TCNs）是一種廣效抗生素，可用於對抗多種微生物。TCNs應用在家庭醫療、農業、畜牧、水產養殖以預防動物疾病，並提供亞治療生長促進劑之用。大量的研究均指出抗生素會對生態環境產生重大威脅。TCN自1948年使用，之後陸續在動物分離株實驗中觀察到其有抗藥類型，同時也是細菌在進化過程中出現最多抗藥性的抗生素之一。TCNs對光敏感。其抗菌光動力治療法經藍光或紫光激發，可產生活性氧物質(ROS)進而對微生物細胞執行毒殺，因此TCNs的抗菌光動力治療法深具潛力，有助於減少皮膚感染多重耐藥性細菌。另一方面，以黃素單核苷酸（riboflavin-5'-phosphate, FMN）光化學法產生大量活性氧物質對TCN作用後能使TCN對微生物的失活性大幅下降，可有助於減緩TCNs對環境生態的影響。

關鍵字

抗生素；失活；四環素；黃素單核苷酸；活性氧物質

並列摘要

Tetracyclines (TCNs) are a broad-spectrum antimicrobial agent and inhibit protein synthesis in microorganisms. TCNs are extensively used in agriculture and animal husbandry to prevent animal diseases and also are a growth promoter. TCN resistance has been the most common type of resistance observed in animal isolates since its approval in 1948. Waste containing antibiotics may present a severe hazard to ecosystems. Photosensitive TCNs oxidation via blue or violet light form O_2^(．-), which deactivates E. coli and its multi-drug-resistant strain and S. aureus, including a methicillin-resistant strain. The antibacterial photodynamic inactivation of bacteria of pathogenic microorganisms was achieved via reactive oxygen species (ROS) generation from photosensitive TCNs oxidation. During the photolytic process of TCNs, ROS is generated and the photolytic product of TCNs is risk to MDR E. coli. Degrading TCNs by riboflavin-5'-phosphate (FMN) photolysis can notably decrease the antimicrobial capability of TCNs and decline its impact on environmental ecosystems.

並列關鍵字

antibiotic ； inactivation ； tetracycline ； FMN ； ROS

國際替代計量

文獻回顧：四環素光化學研究

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