The Treatise on Twelve Cutaneous Regions was the "source of Zhang Zhong Jing's six channel patterns," which is one of the pivotal developments in the history of traditional Chinese medicine (TCM). The twelve cutaneous regions not only define the distribution of channels on the body's surface, they are the most exterior extensions of the channels themselves. The cutaneous regions are a surface that offers reflections of the physiological condition of the twelve channels and are also portals (or pathways) that reflect pathological conditions. These cutaneous regions provide information about the body's systemic physiological condition and the clinical application of cutaneous regions allows the practitioner to understand the pathomechanisms involved in the underlying pathoconditions. This knowledge can then be exploited for providing treatment by selecting a combination of distant needling, hair needling, great needling, one-eitherside needling, and superficial needling methods over the twelve cutaneous regions applying subcutaneous and intradermal needle insertion. This approach will provide effective treatment results for a broad scope of pathological conditions.