- 期刊
- OpenAccess
Antimicrobial Sensitivity Pattern of Clinical Isolates of Mycobacterium Tuberculosis: A-Retrospective Study from a Reference Laboratory in Pakistan
並列摘要
Objective: To determine the sensitivity pattern of first line anti-tuberculosis drugs against clinical isolates of Mycobacterium tuberculosis (MTB) in our settings. Place and duration: Department of Microbiology, Armed Forces Institute of Pathology Rawalpindi, Pakistan, from January 2010 through December 2012. Materials & Methods: Samples received during the study period were processed on MGIT 960 system for MTB culture and drug susceptibility testing (DST) was performed for first line antituberculosis drugs, namely rifampicin (RIF), isoniazid (INH), streptomycin (STR) and ethambutol (ETH). MTB ATCC 25177 was used as control strain. Results: A total of 4050 samples were tested on MGIT 960 System, out of which 689(17%) were culture positive. Out of these culture positive cases, 303(44%) were pansensitive, 52(7.5%) pan-resistant, 84(12.2%) sensitive to one drug only, 171(24.8%) resistant to one drug only and 49(7.1%) were resistant to 2 drugs other than MDR. 132(19.16%) cases were multidrug resistant (MDR). Conclusion: Resistance to first line anti-tuberculosis drugs is alarming. Our results highlight the importance of drug susceptibility testing of MTB isolates against first line anti-tuberculosis drugs in an endemic country, so as to properly manage tuberculosis patients.
延伸閱讀
- Huang, T. Y. (2017). Identification of antimicrobial peptides against methicillin resistant Staphylococcus aureus and multidrug resistant Acinetobacter baumannii in vitro and in vivo [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU201702465
- Wei, C. Y., Hwang, J. J., Chu, C. H., & Lee, C. P. (1999). Detection and Identification of Mycobacterium Tuberculosis by Nested PCR Assays in Cerebrospinal Fluid Samples from Patients with Suspected Tuberculous Meningitis. The Kaohsiung Journal of Medical Sciences, 15(8), 475-483. https://doi.org/10.6452/KJMS.199908.0475
- Huang, Y. T., Yang, C. Y., Hsieh, C. C., Hong, M. Y., & Lee, C. C. (2022). Microorganism Distributions and Antimicrobial Susceptibility in Community-Onset Bacteremia: A 6-Year Longitudinal Multicenter Cohort in Southern Taiwan. Journal of Acute Medicine, 12(1), 1-12. https://doi.org/10.6705/j.jacme.202203_12(1).0001
- Seyoum, B., Demissie, M., Worku, A., Bekele, S., & Aseffa, A. (2014). Prevalence and Drug Resistance Patterns of ＂Mycobacterium tuberculosis＂ among New Smear Positive Pulmonary Tuberculosis Patients in Eastern Ethiopia. Tuberculosis Research and Treatment, (2014), 180-186. https://doi.org/10.1155/2014/753492
- Omar, A. I. A., Arjunan, M., & Salamah, A. A. A. (2013). Prevalence of Antibiotic Resistance and Minimum Inhibitory Concentrations of Helicobacter pylori Isolates from Clinical Gastritis Patients, Saudi Arabia. Global Journal of Gastroenterology & Hepatology, 1(2), 101-106. https://doi.org/10.12970/2308-6483.2013.01.02.6