Factors Associated with Quality of Life in Adult Epilepsy Patients: a Hospital Based Study from South India

Shanmukhi.S ； Sita Jayalakshmi.S ； Anand. B

《Research in Neurology: An International Journal》 2015卷 (2015/12) Pp. 1-9

https://doi.org/10.5171/2015.766328

並列摘要

Epilepsy is a chronic condition which affects quality of life (QOL). QOL is considered as an important outcome measure and component of management in studies of adult epilepsy. Objective: To evaluate factors associated with quality of life in adult epilepsy patients. Materials and Methods: A cross-sectional study was performed to examine the quality of life in 560 adult patients with epilepsy. The data collected included detailed clinical and socio-demographic data, epilepsy details, psychiatric diagnosis (ICD-10 for Mental and behavioral disorders), Liverpool seizure severity scale (LSSS) and Quality of life in epilepsy (QOLIE-31) are assessed. Descriptive statistics-Percentages, ANOVA, Univariate odds and Multiple Logistic Regression analysis with step-down procedure were done. Results: Study population comprised 337 males and 223 females with mean age of 29.26 + 10.83 (range 18-50) years. On Univariate Odds ratio (OR) (95% CI) for single anti-epileptic drug (AED) 2.75(1.85 to 4.09) and absence of psychiatric diagnosis 1.60(1.02 to 2.53) are predictors for good QOL. On one-way ANOVA with QOLIE subscales, seizure frequency and psychiatric diagnosis were found to be statistically significant (p＜0.01) but no significant interaction between them. On Logistic Regression step down procedure, psychiatric diagnosis (OR 95% C.I) 7.29(1.65 to 32.10) and multiple AED 1.86(1.24 to 3.51) was found to be predicting factors for poor QOLIE. Conclusion: The presence of psychiatric diagnosis (Depression and Anxiety) was the strongest predictor of poor QOLIE patients. Early psychiatric evaluation and intervention would improve quality of life in epilepsy patients.

並列關鍵字

Quality of life ； epilepsy ； factors ； predicting factors