四氯化碳誘導肝臟發炎中D‐乳酸之研究

The Study of D-Lactate in CCl4-Induced Liver Inflammation

Ming-Cheng Chuang ； Pen-Yuan Lin ； Jen-Ai Lee

《國際創新發明大會》 2012 (2012/09) Pp. 265-269

https://doi.org/10.30079/CIISANNUAL.201209.0265

摘要

肝臟相關疾病對國人健康影響甚巨，而目前臨床上常使用的兩個生化指標丙胺酸轉胺酶（AlanineTransaminase；ALT）與天門冬胺酸轉胺酶（AspartateTransaminase；AST）又存在著專一性不足的問題，因此尋找肝臟相關疾病臨床診斷上專一的生化指標已儼然成為目前研究的熱門範疇。過去的文獻中指出，肝硬化病人的血清中，D-乳酸的濃度有上升的情況，然而，肝臟損傷的情況下，尿液和組織中D-乳酸的濃度卻鮮少有人探討，因此本實驗主要研究尿液、組織和血清中D-乳酸的濃度的變化與肝臟發炎的關係。

關鍵字

D-乳酸 ； 四氯化碳 ； 化學性肝病變

並列摘要

Liver-related diseases affect citizens in Taiwan greatly. However, the lack of specificity has been a big problem to both ALT (Alanine Transaminase) and AST (Aspartate Transaminase), two common-used biomarkers clinically. Therefore, to find a highly specific biomarker for the diagnosis of liver-related diseases has become popular so far. In previous study, it was found that serum D-lactate increased significantly in patients with liver cirrhosis. Nevertheless, few study talks about D-lactate in urine and liver tissue under the circumstance of liver injuries. Thus, the aim of this study is to figure out the relationship among the changes of D-lactate in urine, serum, liver tissue and liver inflammation.