The fluid-structure interaction is numerically analyzed for a two-stage centrifugal turbine. The performance of the rotor in terms of shaft-work output was evaluated using the CAE method. In the present study, the configuration of the turbine is designed based on the information of the cycle analysis. The fluid pressure and temperature distribution can be obtained from the results of fluid analysis; on the other hand, the distribution of stress and thermal stress can be obtained from the solid analysis. The current research results will be used as a basis for the design of a two-stage centrifugal turbine.