Shortening the time-to-market is an important issue in the manufacturing industry. Indirect tooling technology was regarded as a promising approach of reducing time and cost to the market in a new product development phase. Silicone rubber mold was frequently employed in the indirect tooling. In this study, the service life of silicone rubber molds was investigated using both wax injection molding and vacuum casting. The experimental results revealed that the average roughnesses of the inner surface of silicone rubber mold were increased with increasing the number of runs and saturated after 25 test runs. The degassing time needs to be increased with increasing the number of runs in the vacuum casting process. The major criteria for judging the service life of silicone rubber molds are surface features and elasticity of silicone rubber molds.