The Asian variant of intravascular lymphoma (AIVL) is a rare subtype of extranodal diffuse large B cell lymphoma characterized by proliferation of clonal lymphocytes within small vessels, reported mainly in Asia, clinically characterized by fever, cytopenias, hepatosplenomegaly and bone marrow invasion. We report a 59-year-old man presenting with fever of unknown origin for 2 weeks. Initial investigation revealed hepatosplenomegaly, abnormal liver function tests, cytopenias and markedly elevated lactate dehydrogenase. Blood cultures, serology, autoimmune screen and Galium scan were not diagnostic. The fever persisted despite empirical antibiotic treatment. The diagnosis of IVL was based on iliac bone marrow biopsy. He was treated with high-dose methyprednisolone. Unfortunately, acute tumor lysis syndrome developed, which led to the patient’s death. Early detection of the disease is a challenge, and a prompt bone marrow examination along with proper evaluation of certain clinical manifestations may enhance the chances of improving prognosis.