血管淋巴增生併嗜伊紅血球增多症－病例報告

Angiolymphoid Hyperplasia with Eosinophilia - Case Report

陳彥良(Yen-Liang Chen) ； 陳立民(Li-Mien Chen) ； 黃健郎(Chien-Lang Huang) ； 楊雅堂(Yia-Tang Yiang)

《中華民國耳鼻喉科醫學雜誌》 35卷1期 (2000/01) Pp. 79-82

https://doi.org/10.6286/2000.35.1.79

摘要

血管淋巴增生併嗜伊紅血球增生症（angiolymphoid hyperplasia with eosinophilia），是一種好發於頭頸部皮膚或皮下結締組織的罕見、良性、局部增生性疾病。由於臨床上相當罕見，因此常被誤認為Kimura氏症，甚至被誤認為惡性腫瘤。尤其當患者有頭頸部腫塊，病理組織發現有厚壁血管增生、廣泛性淋巴球與嗜伊紅血球浸潤時，就必須考慮此病。必要時可實施免疫組織化學染色來進一步確認診斷，並排除惡性淋巴瘤之可能。如此才能使患者得到最正確的診斷並免除許多不必要的檢查與治療。

關鍵字

血管淋巴增生併嗜伊紅血球增多症 ； Kimura氏症 ； 惡性淋巴瘤

並列摘要

Angiolymphoid hyperplasia with eosinophilia which is apparently a benign and locally proliferating lesion occurs predominantly in the head and neck region. However, it is rare clinically so it is often misdiagnosed as Kimura’s disease or a malignant disease. We report on an 86-year-old man with ALHE. The diagnosis was made by clinical features of head or neck masses, skin rashes, normal IgE, and typical histopathologic find-ings of thick-walled blood vessel hyperplasia, marked lymphocytes and eosinophil infil-tration with missing lymphoid follicles and active germinal centers.
Differential diagnosis of ALHE is important to rule out the Kimura’s disease and malign-nant lymphoma. Clinically, a diagnosis of ALHE should be considered if a patient has head or neck masses, and histopathological findings of thick-walled blood vessel hyper-plasia, marked lymphocytes, and eosinophil infiltration. This should be confirmed with immunohistochemical methods to avoid unnecessary intensive examinations and treat-ments.

並列關鍵字

angiolymphoid hyperplasia with eosinophilia ； Kimura's disease ； malignant lymphoma