This study discusses how the salient region method is applied to judge the position of the calcifications on Computed Tomography images. The square method was proposed to detect the position of the calcifications and fulfill in this study. Finally, the experimental results were analyzed on the effectiveness. On novelty, this study proposes one of the salient region detection methods to perform segmentation for the target objects, thereby fulfilling the applications on judgement of calcifications on the computed tomographic angiography images. This method also assists the medical doctors to make correct medical diagnosis and enhances the preventions on the related diseases.