- 期刊
【論文摘要】NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models
摘要
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid- β (Aβ) and hyper-phosphorylated tau accumulation are accountable for the progressive neuronal loss and cognitive impairments usually observed in AD. Currently, medications for AD offer moderate symptomatic relief but fail to cure the disease; hence development of effective and safe drugs is urgently needed for AD treatment. In this study, we investigated a Chinese medicine (CM) formulation named NeuroDefend (ND), for reducing amyloid β (Aβ) and tau pathology in transgenic AD mice models. Regular oral administration of ND improved cognitive function and memory in 3XTg-AD and 5XFAD mice. In addition, ND reduced beta-amyloid precursor protein (APP), APP C-terminal fragments (CTF-β/α), Aβ and 4G8 positive Aβ burden in 3XTg-AD and 5XFAD mice. Furthermore, ND efficiently reduced the levels of insoluble phospho-tau protein aggregates and AT8 positive phospho tau neuron load in 3XTg-AD mice. Hence, ND could be a promising candidate for the treatment of AD in humans.
關鍵字
無資料延伸閱讀
- Lu, Y. C., Tseng, L. W., Huang, Y. C., Yang, C. W., Chen, Y. C., & Chen, H. Y. (2022). 【論文摘要】The Potential Complementary Role of Using Chinese Herbal Medicine with Western Medicine in Treating COVID-19 Patients: Pharmacology Network Analysis. 中西整合醫學會會訊, (87), 4-4. https://doi.org/10.3390/ph15070794
- 邱允柔、游偲翌、陳惠敏（2019）。【論文摘要】Application of Inhaled Nitric Oxide Therapy and High Frequency Oscillatory Ventilation for Premature with Respiratory Distress Syndrome combined with Persistent Pulmonary Hypertension of Newborn。呼吸治療，18(1)，124-124。https://doi.org/10.6269/JRT.201907_18(1).0045
- Orekhov, A. N., Ryzhkova, A. I., Sinyov, V. V., Sazonova, M. D., Khasanova, Z. B., Doroschuk, N. A., Karagodin, V. P., Sobenin, I. A., & Sazonova, M. A. (2019). 【論文摘要】Analysis of Mutations in Mitochondrial Genome in Intima-medial Layer of Patients with Atherosclerosis from the Novosibirsk Region. 海峽循環醫學雜誌, 1(2S), 145-145. https://doi.org/10.6907/SCJ.201909/SP_1(2).0118
- Hung, Y. T., Liu, W. Y., Fang, C. Y., & Chang, Y. J. (2022). 【論文摘要】Effects of Transcutaneous Spinal Cord Stimulation in Individual with Spinal Cord Injury-A Systematic Review and Meta-Analysis. 物理治療, 47(4), 292-292. https://doi.org/10.6215/FJPT.202212.O19
- 盧愷莉（2021）。【論文摘要】Needs Assessment of Neonatal Medical Staff for Early Development Assessment and Interventional Knowledge of Preterm Infants。物理治療，46(2)，175-176。https://doi.org/10.6215/FJPT.202106.P74