The method of the research dominated by the ontology, epistemology and methodology of the subject. This essay try to find out the ontology, epistemology and methodology of TCM, make a self-criticism of the method of TCM research.TCM stress theory that man is an integral part of nature, pay attention to the knowledge constructed by the thinking process, different with the idea of positivism. The research of TCM need aware of the blind spot of positivism, TCM couldn't rely on positivism too over. The research of TCM need apply any kind of method, the style of TCM research is multivariate. The knowledge of TCM should emphasis the construct by human's thinking or idea, as a result, TCM should emphasis on the method of deduction. In order to find out the exception and new knowledge, TCM should intensify on the falsification. In order to guarantee the TCM structure well-knit, dialectical textualism need to be used. Because of present of individual feature, TCM should emphasis case studies and qualitative research. In order to keep an eye on every unit of the discipline, when study TCM should emphasis interdisciplinary.