根據台灣癌症登記資料庫2011年的報告,頭頸癌是第四常見的癌症,也是癌症死亡率的第四名。在頭頸癌中有75%是口腔癌,可見口腔癌是台灣很重要的健康問題。外科手術是口腔癌治療的主要方式,但各種手術、放射治療和化學治療的組合也會根據不同的疾病表現和病理發現而使用。對於不能手術切除的腫瘤,放射治療就成為唯一的選擇。除了治療選擇外,許多不同的放射治療技術也可在口腔癌的治療上提供協助。強度調控(intensity modulation),影像導引(image guidance)和適應性放射治療技術(adaptive radiotherapy)可以改進照射劑量的分佈和治療的精準度。近接治療和質子治療具有與高能光子不同劑量分佈的特性,可運用於某些適合的狀況。在本篇文章中,我們將根據現有的文獻討論目前放射治療在口腔癌的應用和不同放療技術的優勢。
According to the National Cancer Registry of Taiwan, head and neck cancer was the fourth most common cancer and the cancer with the fourth highest mortality rate in 2011. Seventy-five percent of head and neck cancers in Taiwan are oral cavity cancers. Therefore, oral cavity cancer is an important health issue in Taiwan. Surgery is the main treatment modality, but various combinations of surgery, radiotherapy, and chemotherapy may also be used depending on the disease presentation and pathologic findings. For unresectable tumors, primary radiotherapy is the treatment of choice. Intensity-modulation, image guidance, and adaptive radiotherapy procedures can improve the radiation dose delivery and precision of the treatment. Brachytherapy and proton therapy can confine the radiation dose in limited area, which is an advantage in radiotherapy for some oral cavity cancers. In this review, we discuss the application of radiotherapy in oral cavity cancer and the advantages of different radiotherapy techniques.