The Clinical Pictures and Survival Analysis of Colorectal Cancer Patients Less Than or Equal to 40 Years of Age-Data from A Single Hospital

小於或等於40歲大腸直腸癌患者之臨床表現及存活分析：來自單一醫院的資料

呂敏吉(Ming-Chi Lu) ； 林哲斌(Che-Pin Lin) ； 丁金聰(Chin-Tsung Ting) ； 陳光宏(Kuang-Hung Chen) ； 鄭企峰(Chi-Feng Cheng)

《台灣癌症醫學雜誌》 2卷3期 (2015/09) Pp. 205-212

https://doi.org/10.6323/JCRP.2015.2.3.03

摘要

目的：評估小於等於40歲的大腸直腸癌的臨床表現及存活率。方法：收集本院自2007年一月到2012年十二月共819位大腸直腸癌的病人，其中23位（2.8%）小於等於40歲。分析臨床表現及存活率，並與大於40歲大腸直腸癌的病患做相關探討。結果：在小於等於40歲和大於40歲的大腸直腸癌中，在性別、分期、組織學等級、KRAS突變率並無差異；甚至在組織學上特殊的黏液性癌方面，小於40歲為8.3%而大於40歲為3.5%，但無統計學上意義（p=0.219）。而在存活率分析方面，在同一個期別小於等於40歲和大於40歲的大腸直腸癌，兩者存活率並無不同。結論：無論在臨床表現及存活率，在小於40歲或大於40歲的大腸直腸癌並無差異。

關鍵字

大腸直腸癌 ； 小於40歲 ； KRAS突變

並列摘要

Purpose: The purpose of our study was to evaluate the clinical features and survival of colorectal cancer patients 40 years of age and under. Patients and Methods: From January 1, 2007 to December 31, 2012, a total of 819 colorectal cancer patients were admitted to our hospital, of which 23 cases (2.8%) were equal to or less than 40 years of age. We analyzed their clinical pictures and compared their prognoses to that of their colorectal cancer counterparts older than 40 years of age. Results: The gender distribution, staging, histological grading, and KRAS mutation rate showed no difference between the two groups. Even the incidence of mucinous carcinoma with special histology was 8.3% ( in＜40 age group) vs. 3.5% (in＞40 age group), without statistical significance (p=0.219). Overall, the survival analysis demonstrated there to be no difference in each stage between patients 40 years of age and under, and those patients over 40 years of age. Conclusions: There was no difference in the clinical features and survival duration of colorectal cancer patients between those patients less than 40 years of age and those more than 40 years of age.

並列關鍵字

colorectal cancer ； less than 40 years old ； KRAS mutation